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Wijnand Helfrich Selected Research

Immunoglobulin Fragments

1/2019Development of Bispecific Antibody Derivatives for Cancer Immunotherapy.
4/2014Targeted delivery of CD40L promotes restricted activation of antigen-presenting cells and induction of cancer cell death.
5/2013Antibody-based fusion proteins to target death receptors in cancer.
11/2010Melanoma-associated Chondroitin Sulfate Proteoglycan (MCSP)-targeted delivery of soluble TRAIL potently inhibits melanoma outgrowth in vitro and in vivo.
12/2008Potent systemic anticancer activity of adenovirally expressed EGFR-selective TRAIL fusion protein.
8/2008Targeted delivery of a designed sTRAIL mutant results in superior apoptotic activity towards EGFR-positive tumor cells.
4/2006CD7-restricted activation of Fas-mediated apoptosis: a novel therapeutic approach for acute T-cell leukemia.

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Wijnand Helfrich Research Topics

Disease

45Neoplasms (Cancer)
03/2022 - 04/2002
12Prostatic Neoplasms (Prostate Cancer)
04/2021 - 07/2009
7Carcinoma (Carcinomatosis)
03/2022 - 03/2004
7Melanoma (Melanoma, Malignant)
03/2022 - 11/2010
4Ovarian Neoplasms (Ovarian Cancer)
10/2018 - 01/2010
3Ovarian Epithelial Carcinoma
10/2018 - 01/2010
2Triple Negative Breast Neoplasms
03/2016 - 01/2016
2Neoplasm Metastasis (Metastasis)
11/2014 - 07/2009
2Rheumatoid Arthritis
09/2014 - 01/2011
2Infections
06/2013 - 12/2008
2Brain Neoplasms (Brain Tumor)
07/2007 - 05/2006
2Lymphoma (Lymphomas)
02/2007 - 04/2005
2T-Cell Leukemia (Leukemia, T Cell)
04/2006 - 04/2005
2Leukemia
04/2006 - 04/2005
1Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
11/2019
1Bites and Stings (Sting)
01/2019
1Lung Neoplasms (Lung Cancer)
01/2019
1Breast Neoplasms (Breast Cancer)
03/2016
1Colorectal Neoplasms (Colorectal Cancer)
01/2015
1Sarcoma (Soft Tissue Sarcoma)
01/2015
1Head and Neck Neoplasms (Head and Neck Cancer)
10/2014
1Rhabdomyosarcoma
10/2014
1Multiple Sclerosis
09/2014
1B-Cell Leukemia (Leukemia, B Cell)
04/2014

Drug/Important Bio-Agent (IBA)

15AntigensIBA
03/2022 - 03/2004
14Proteins (Proteins, Gene)FDA Link
10/2017 - 03/2004
13AntibodiesIBA
03/2022 - 04/2002
8LigandsIBA
10/2017 - 03/2005
7Epithelial Cell Adhesion MoleculeIBA
03/2022 - 03/2004
7Immunoglobulin FragmentsIBA
01/2019 - 04/2006
5ErbB Receptors (EGF Receptor)IBA
01/2019 - 03/2005
5Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
01/2015 - 04/2002
5Peptides (Polypeptides)IBA
11/2014 - 07/2009
5Bombesin Receptors (Bombesin Receptor)IBA
10/2013 - 07/2009
4RadiopharmaceuticalsIBA
01/2021 - 08/2011
4TNF-Related Apoptosis-Inducing LigandIBA
08/2016 - 03/2004
4Monoclonal AntibodiesIBA
01/2015 - 03/2005
4BombesinIBA
10/2013 - 08/2011
3chondroitin sulfate proteoglycan 4IBA
11/2019 - 01/2016
3Rituximab (Mabthera)FDA Link
01/2019 - 08/2006
3VaccinesIBA
10/2018 - 01/2010
3TNF-Related Apoptosis-Inducing Ligand ReceptorsIBA
02/2016 - 03/2004
2AzidesIBA
04/2021 - 08/2020
2Alkynes (Acetylenes)IBA
04/2021 - 08/2020
2Bispecific AntibodiesIBA
01/2019 - 05/2008
2Glycoproteins (Glycoprotein)IBA
06/2017 - 08/2008
2Immunoglobulin G (IgG)IBA
01/2015 - 04/2002
2temoporfinIBA
10/2014 - 05/2012
2Immunotoxins (Immunotoxin)IBA
10/2014 - 05/2013
2Pharmaceutical PreparationsIBA
10/2014 - 07/2009
2Radioisotopes (Radionuclides)IBA
06/2014 - 08/2012
2Technetium (Technetium 99m)IBA
10/2013 - 08/2011
2tricineIBA
10/2013 - 08/2011
2bombesin (7-14)IBA
10/2013 - 08/2011
2rimcazoleIBA
09/2013 - 11/2010
2Death Domain ReceptorsIBA
05/2013 - 02/2007
2Surface Antigens (Surface Antigen)IBA
05/2013 - 03/2004
2Bortezomib (Velcade)FDA Link
08/2006 - 04/2006
2Gefitinib (Iressa)FDA Link
08/2006 - 03/2005
1Fluorescein (Funduscein)FDA LinkGeneric
03/2022
1IsotopesIBA
03/2022
1Adenosine Triphosphate (ATP)IBA
08/2021
1Adenosine (Adenocard)FDA LinkGeneric
08/2021
1beta-apocarotenoid-14',13'-dioxygenase (ADO)IBA
08/2021
15'-Nucleotidase (5' Nucleotidase)IBA
08/2021
1Androgen Receptors (Androgen Receptor)IBA
01/2021
1enzalutamideIBA
01/2021
1Viral ProteinsIBA
01/2020
1Programmed Cell Death 1 ReceptorIBA
11/2019
1Immune Checkpoint InhibitorsIBA
11/2019
1blinatumomabIBA
01/2019
1Erlotinib Hydrochloride (CP 358,774)FDA Link
01/2019
1durvalumabIBA
01/2018
1Fluorescein-5-isothiocyanate (FITC)IBA
10/2017
1Granzymes (Granzyme)IBA
03/2016
1Estrogens (Estrogen)FDA Link
01/2016
1ProgesteroneFDA LinkGeneric
01/2016
1human ERBB2 proteinIBA
01/2016
1CalreticulinIBA
01/2015
1Immunoglobulin Fab FragmentsIBA
01/2015
1Galectins (Galectin)IBA
01/2015
1Complement System Proteins (Complement)IBA
01/2015
1Therapeutic UsesIBA
01/2015
11,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acidIBA
11/2014
1Bleomycin (Blenoxane)FDA LinkGeneric
10/2014
11-phenyl-3,3-dimethyltriazene (PDT)IBA
10/2014
1chlorinIBA
10/2014
1Photosensitizing Agents (Photosensitizers)IBA
10/2014
1Interleukin-17 (Interleukin 17)IBA
09/2014
1InterleukinsIBA
09/2014
1Biological ProductsIBA
09/2014
1CD40 Ligand (CD40L)IBA
04/2014

Therapy/Procedure

18Therapeutics
01/2019 - 09/2004
11Immunotherapy
08/2021 - 04/2002
4Drug Therapy (Chemotherapy)
10/2018 - 01/2010
2Computer-Assisted Surgery (Image Guided Surgery)
11/2014 - 06/2014
2Radiotherapy
10/2013 - 05/2006
1Aftercare (After-Treatment)
01/2018
1Photochemotherapy (Photodynamic Therapy)
10/2014
1Prostatectomy (Retropubic Prostatectomy)
10/2013